Tragedy struck when a Pakistan International Airlines Airbus A320 passenger plane flying from Lahore crashed in a Karachi neighbourhood.
Flight PK8303 which was carrying 91 passengers and eight crew, crashed while approaching the Jinnah International Airport.
The health commissioner in charge of the province said at least 11 corpses have been pulled from the wrecked plane.
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Thick black smoke bellowed across the area. Video footage showed emergency workers looking for survivors in the plane crash which has destroyed a number of houses.
The cause of the crash is yet to be confirmed. However, in a previous contact the pilot had told the traffic control that the plane was experiencing technical difficulties.
An eyewitness narrated that he had heard a massive bang and went outside his home to check it out. He said he counted about four houses that have been destroyed.
A state of emergency has been imposed on all of the hospitals in the city of Karachi by the chief minister of the province where the plane crashed.
The tragedy comes as the south Asian country resumes commercial flight after the coronavirus lockdown was relaxed.
Many Pakistanis are travelling to their hometowns to join their families and celebrate the Ramadan holidays to mark the end of fasting on the Muslim calendar.